Mr Griffin had been scheduled to give a speech next week, however the university has been forced into a u-turn over safety concerns.
It admitted it cannot guarantee the wellbeing of staff and students, and warned the controversial leader he won’t be allowed on campus.
Members of the BNP have also been banned from the event on Thursday.
A spokesperson for the university said it carefully considered objections from the faculty before deciding to pull Mr Griffin’s invite.
“Following careful review of operational and safety issues, the Philosophical Society and the college are now not satisfied that the general safety and wellbeing of staff and students can be guaranteed,” a statement read.
“Access to the college will not be given to Mr Griffin or members of the BNP.”
The Philosophical Society at Trinity had invited Mr Griffin to talk as part of their debate: This House Believes That Immigration Has Gone Too Far.
However there was opposition from a grouping called Students Against Fascism.
Mr Griffin said he is “disappointed” by the decision.
“I was looking forward to giving reasoned argument to show that immigration has not been to the benefit of the Irish (and indeed British) people,” he said.
“I wanted to convince people, through debate, that economically and culturally any benefit from immigration was far outweighed by negative impacts.”
The BNP further claim the decision was made after “a far-left mob” of around 30 protestors interrupted a meeting of the society and “intimidated students”.
A brief statement the University Philosophical Society said: “The Phil feels it is unfortunate that circumstances have arisen under which the planned debate can no longer go ahead without compromising the safety of staff and students.”
From Ulster Television News . 15.10.11.